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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
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Aging effects on cerebral asymmetry: a voxel-based morphometry and diffusion tensor imaging study.

Hidemasa Takao1, Osamu Abe, Hidenori Yamasue

  • 1Department of Radiology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan. takaoh-tky@umin.ac.jp

Magnetic Resonance Imaging
|June 26, 2009
PubMed
Summary
This summary is machine-generated.

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Aging does not significantly affect brain hemisphere asymmetry. This study found no age-related changes in gray matter volume or white matter fractional anisotropy asymmetry in healthy adults.

Area of Science:

  • Neuroscience
  • Human Anatomy
  • Brain Imaging

Background:

  • The human brain exhibits functional and structural asymmetry between its hemispheres.
  • Understanding how aging impacts this asymmetry is crucial for cognitive health research.

Purpose of the Study:

  • To investigate the effects of aging on gray matter volume asymmetry.
  • To evaluate the impact of aging on white matter fractional anisotropy asymmetry.

Main Methods:

  • Utilized voxel-based morphometry to assess gray matter volume asymmetry.
  • Employed voxel-based analysis of diffusion tensor imaging (DTI) fractional anisotropy maps.
  • Included 226 right-handed healthy volunteers aged 21-71 years.

Main Results:

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  • No significant correlation was found between age and gray matter volume asymmetry.
  • No significant correlation was observed between age and white matter fractional anisotropy asymmetry.

Conclusions:

  • Aging does not appear to significantly alter gray matter volume asymmetry.
  • Aging does not significantly affect white matter fractional anisotropy asymmetry in healthy individuals.