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Effectiveness of second-generation antipsychotics with acute-phase schizophrenia
Kotaro Hatta1, Koji Sato, Hiroshi Hamakawa
1Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan. khatta@juntendo.ac.jp
Schizophrenia Research
|June 26, 2009
Summary
Olanzapine and risperidone showed superior effectiveness in treating acute psychosis compared to quetiapine and aripiprazole. These findings support their use in hospitalized schizophrenia patients.
Area of Science:
- Psychiatry
- Pharmacology
- Clinical Trials
Background:
- Limited evidence exists on the comparative effectiveness of second-generation antipsychotics (SGAs) in the acute phase of schizophrenia.
- Olanzapine may offer advantages in long-term treatment discontinuation for chronically ill patients.
Purpose of the Study:
- To compare the effectiveness of four SGAs in treating newly admitted patients with acute schizophrenia.
- To determine if any specific SGA was more effective in the acute treatment phase.
Main Methods:
- A rater-blinded, randomized controlled trial was conducted across 15 psychiatric emergency sites.
- 78 patients diagnosed with schizophrenia, acute schizophrenia-like psychotic disorder, or schizoaffective disorder were randomized to receive risperidone, olanzapine, quetiapine, or aripiprazole for 8 weeks.
- The primary outcome measure was all-cause treatment discontinuation.
Main Results:
- Overall, 37% of patients discontinued their medication before 8 weeks.
- Olanzapine and risperidone groups had significantly longer times to treatment discontinuation compared to quetiapine and aripiprazole.
- Aripiprazole group showed a higher rate of p.r.n. intramuscular haloperidol use.
Conclusions:
- Olanzapine and risperidone are more effective than quetiapine and aripiprazole for the acute treatment of psychosis in hospitalized patients.
- These findings highlight the differential effectiveness of SGAs in acute schizophrenia treatment.
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