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Updated: Jun 22, 2026

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice
Published on: June 4, 2020
Making context memories independent of the hippocampus
Hugo Lehmann1, Fraser T Sparks, Simon C Spanswick
1Psychology Department, Trent University, Peterborough, Ontario, Canada. hugolehmann@trentu.ca
Abstract:
We present evidence that certain learning parameters can make a memory, even a very recent one, become independent of the hippocampus. We confirm earlier findings that damage to the hippocampus causes severe retrograde amnesia for context memories, but we show that repeated learning sessions create a context memory that is not vulnerable to the damage. The findings demonstrate that memories normally dependent on the hippocampus are incrementally strengthened in other memory networks with additional learning. The latter provides a new account for patterns of hippocampal retrograde amnesia and how memories may become independent of the hippocampus.
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