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Related Experiment Video

Updated: Jun 22, 2026

Preparation of Parasagittal Slices for the Investigation of Dorsal-ventral Organization of the Rodent Medial Entorhinal Cortex

Preparation of Parasagittal Slices for the Investigation of Dorsal-ventral Organization of the Rodent Medial Entorhinal Cortex

Published on: March 28, 2012

Lateralized spatial and object memory encoding in entorhinal and perirhinal cortices.

Patrick S F Bellgowan¹, Elizabeth A Buffalo, Jerzy Bodurka

¹Section on Cognitive Neuropsychology, NIMH, Bethesda, Maryland 20892, USA. pfbellgowan@saintfrancis.com

Learning & Memory (Cold Spring Harbor, N.Y.)

|June 26, 2009

Summary

This study improved functional MRI (fMRI) signal quality in medial temporal lobe memory regions. Researchers found distinct hemispheric biases for object versus spatial memory encoding and recognition in the perirhinal and entorhinal cortices.

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Last Updated: Jun 22, 2026

Preparation of Parasagittal Slices for the Investigation of Dorsal-ventral Organization of the Rodent Medial Entorhinal Cortex

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Published on: March 28, 2012

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Published on: August 30, 2017

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice

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Published on: June 4, 2020

Area of Science:

Neuroscience
Cognitive Neuroscience
Neuroimaging

Background:

The perirhinal and entorhinal cortices are vital for declarative memory within the medial temporal lobe.
Blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI) has faced challenges in these regions due to signal dropout, impacting temporal signal-to-noise ratio (tSNR).

Purpose of the Study:

To investigate the roles of the anterior medial temporal lobe, specifically the entorhinal and perirhinal cortices, in object and spatial memory.
To explore hemispheric lateralization of function within these regions for different memory types.

Main Methods:

Utilized an improved BOLD fMRI technique with higher spatial resolution in the z-plane and a 16-element surface coil array at 3 Tesla to enhance signal quality in the anterior medial temporal lobes.
Participants encoded fractal images, focusing on either object identity or location, followed by recognition memory tests after 18-second delays.

Main Results:

Both perirhinal and entorhinal cortices showed activation during object and spatial encoding tasks.
Object encoding and recognition were predominantly lateralized to the left hemisphere.
Spatial encoding and recognition were predominantly lateralized to the right hemisphere.

Conclusions:

The findings suggest a hemispheric division of labor for processing object versus spatial information within the human perirhinal and entorhinal cortices.
This supports theories of functional dissociation within the medial temporal lobe for distinct memory processes.