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Updated: Jun 22, 2026
Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
Published on: December 11, 2017
Stroke work or systolic dP/dtmax to evaluate acute response to cardiac resynchronization therapy: are they
Gerjan de Roest1, Paul Knaapen, Marco Götte
1Department of Cardiology, VU University Medical Center, 1081 HV Amsterdam, The Netherlands. gj.deroest@vumc.nl
Background:
Cardiac resynchronization therapy (CRT) is characterized by a approximately 30% non-response. Invasive haemodynamic measurements are a traditional method to evaluate response to CRT. This study evaluates the correlation between acute changes in dP/dt(max) and Stroke Work (SW) during CRT.
Methods:
Thirty-four CRT candidates were haemodynamically evaluated by pressure-volume loop analysis during biventricular pacing.
Results:
Mean dP/dt(max) and SW at baseline were 854 +/- 198 and 5186 +/- 2349, and displayed an increase during pacing of 106 +/- 117 mmHg/s (13% +/- 14%) and 1303 +/- 3039 mL/mmHg (30% +/- 52%), respectively. No correlation was found between the percentage change in dP/dt(max) and SW (R = 0.06, P = ns). When defining response an augmentation of 10% relative to baseline for both parameters, 16 patients demonstrated an ambiguous response.
Conclusion:
Although both parameters display an average increase during pacing, the change relative to baseline values of SW and dP/dt(max) is not related.
