Related Experiment Video
Updated: Jun 22, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
Published on: February 6, 2019
General principles of radiation and chemoradiation
1Department of Radiation Oncology, the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA. hahn@xrt.upenn.edu
Abstract:
High-resolution, three-dimensional functional imaging has improved delivery of radiotherapy to tumors while minimizing damage to adjacent, healthy tissue. A growing array of energy sources and delivery systems, including external delivery of protons and brachytherapy, are also credited with improvement in the therapeutic index of treating diseases with radiation. In many malignancies, the therapeutic effects of radiotherapy can be significantly augmented by coordinated delivery of adjunctive therapies, particularly chemotherapy. In age-related macular degeneration (AMD) and other diseases of the eye, radiotherapy combined with pharmaceutical agents, including antiangiogenesis therapies, have the potential to an additive or synergistic effect. In AMD, the most significant challenge for radiotherapy may be precise delivery to the target and avoidance of damage to surrounding tissues.
More Related Videos
Related Concept Videos
Radiation: Applications
The average...
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Biological Effects of Radiation
Isotopes and Radioisotopes
An isotope containing more...
Absorption of Radiation

