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Updated: Jun 22, 2026
09:27
The Dimethylnitrosamine Induced Liver Fibrosis Model in the Rat
Published on: June 17, 2016
[Fibrate-induced deterioration of renal function]
N Polanco1, E Hernández, E González
1Department of Nephrology. 12 de Octubre University Hospital. Madrid, Spain. nipolanco@yahoo.es
Summary
Fibrate medications can cause acute kidney injury, with some patients experiencing irreversible renal function loss. Regular kidney function monitoring is crucial, especially for those with chronic renal failure, during fibrate therapy.
Area of Science:
- Nephrology
- Pharmacology
- Internal Medicine
Context:
- Fibrates are commonly prescribed for hyperlipidemia.
- Adverse effects on renal function are not widely recognized.
- A significant number of patients experienced acute renal failure linked to fibrate use.
Purpose:
- To analyze the clinical experience of acute renal failure associated with fibrate medications.
- To identify risk factors and outcomes in patients developing renal impairment.
Summary:
- A retrospective review identified thirteen patients with acute renal failure attributed to fibrates (Fenofibrate, Bezafibrate, Gemfibrozil).
- Ten patients received Fenofibrate, one Bezafibrate, and two Gemfibrozil.
- Over 74% increase in serum creatinine was observed.
- Acute renal failure was reversible in nine patients, but four had persistent renal dysfunction.
- Patients with poorer outcomes had higher creatinine levels and longer exposure to fibrates.
- Renal biopsies showed no significant lesions.
Impact:
- Fibrate therapy can precipitate acute renal failure, with a notable percentage of patients (30.8%) not recovering baseline renal function.
- Highlights the importance of renal function monitoring during fibrate treatment, particularly in patients with pre-existing chronic renal failure.
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