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Related Experiment Video

Updated: Jun 22, 2026

Self-Assembly of Microtubule Tactoids

Self-Assembly of Microtubule Tactoids

Published on: June 23, 2022

Self-organization in coordination-driven self-assembly.

Brian H Northrop¹, Yao-Rong Zheng, Ki-Whan Chi

¹Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah 84112, USA.

Accounts of Chemical Research

|June 27, 2009

Summary

Researchers explored self-organization in platinum(II)-based metallosupramolecules, finding that factors like subunit geometry and steric interactions control assembly. This work advances understanding of self-organization in synthetic and biological systems.

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Area of Science:

Coordination Chemistry
Supramolecular Chemistry
Materials Science

Background:

Self-assembly is crucial for creating complex molecular systems from simpler precursors.
Biological systems exhibit sophisticated self-organization phenomena.
Synthetic self-organization, particularly in metallosupramolecules, is an active research area.

Purpose of the Study:

To investigate self-organization in coordination-driven self-assembly of platinum(II)-based metallosupramolecules.
To systematically study factors influencing supramolecular self-organization.
To understand control over the formation of discrete synthetic supramolecular assemblies.

Main Methods:

Utilized a modular, coordination-driven self-assembly approach.
Systematically varied parameters including donor subunit symmetry/polarity, Pt(II) acceptor/organic donor geometry, temperature, solvent, and intermolecular interactions (steric, hydrophobic).
Analyzed the extent of self-organization, ranging from statistical mixtures to amplified and absolute self-organization.

Main Results:

Demonstrated control over self-organization in 2D and 3D platinum(II)-based metallosupramolecular assemblies.
Identified key factors like dipolar interactions, steric effects, and geometric parameters that drive absolute self-organization.
Showcased the tunability of steric interactions for amplified self-organization.

Conclusions:

Achieved absolute self-organization of discrete supramolecular assemblies through judicious design and control of subunit interactions.
The findings provide insights into analogous self-organization processes in biological systems.
Facile synthesis of complex, multifunctional systems is possible via controlled self-assembly of simple components.