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alpha/beta-Arteether-induced mania in a predisposed adolescent
Mohammad Zia Ul Haq1, Biswa Ranjan Mishra, Nishant Goyal
1Centre for Cognitive Neurosciences, Central Institute of Psychiatry, Ranchi 834006, India. drziaulhaq@gmail.com
General Hospital Psychiatry
|June 27, 2009
Summary
Artemisinin derivatives, used for malaria, may rarely cause mania. This case highlights potential hereditary links and neurotoxic risks in adolescents, emphasizing careful monitoring for adverse events.
Area of Science:
- Pharmacology
- Neuroscience
- Tropical Medicine
Background:
- Artemisinin derivatives are frontline antimalarials effective against resistant Plasmodium strains.
- Concerns exist regarding potential neurotoxicity of artemisinin derivatives, supported by some animal and human studies.
Observation:
- A case study of an adolescent experiencing mania after treatment with alpha/beta-arteether is presented.
- The adolescent had a documented family history of chloroquine-induced psychosis.
Findings:
- This case suggests a potential link between artemisinin derivatives and induced mania.
- Hereditary predispositions may increase susceptibility to neurotoxic adverse events from these drugs.
Implications:
- Highlights the rare but serious neurotoxic potential of artemisinin derivatives.
- Underscores the importance of considering family history and genetic factors in adverse drug reactions.
- Calls for vigilant clinical monitoring for psychiatric side effects in patients treated with artemisinin derivatives.
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