Related Experiment Video
Updated: Jun 22, 2026

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis
Published on: October 26, 2020
Renin angiotensin system inhibition in the older person: a review
Maha A Mohamed1, Matthew R Weir
1Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, 22 S. Greene Street, N3W143, Baltimore, MD 21201, USA.
Abstract:
The efficacy and safety of rennin angiotensin system (RAS) inhibition for lowering blood pressure in older populations has been demonstrated in a number of clinical trials. Whether a patient's age influences the overall ability of these drugs to lower blood pressure and protect against progress of cardiovascular and kidney disease has been the focus of few clinical trials. Herein, the author's review the mechanism of action of the renin angiotensin cascade and then discuss the clinical evidence surrounding the use of RAS-blocking drugs in the older population.
Related Concept Videos
Antihypertensive Drugs: Direct Renin Inhibitors
Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
Antihypertensive Drugs: Angiotensin II Receptor Blockers
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion
Hypertension II: Pathophysiology

