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Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
Published on: May 26, 2022
Angiotensin-induced drinking in rats with hereditary hypothalamic diabetes insipidus
A K Johnson1, M Ian Phillips, J Mohring
1Department of Psychology and Department of Physiology and Biophysics, University of Iowa, Iowa City, Iowa 52242, USA.
Abstract:
Previous reports indicate that the pressor response seen following intracranially applied angiotensin II (AII) in normal rats is absent in hereditary hypothalamic diabetes insipidus (DI) animals. The dipsogenic effect of intracranially injected AII was therefore examined in DI rats and in control rats. Our results show that the drinking response to AII was present in DI animals and not different from control rats. Substitution of DI animals with vasopressin had no effect on the drinking response to AII. We conclude that it is possible to dissociate brain mechanisms mediating the centrally induced blood pressure response and the drinking response.
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