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Interhemispheric field potentials, spreading depression and kindling.

J Machek¹, E Ujec, V Pavlík

¹Institute of Physiology, Czechoslovak Academy of Sciences, Prague, Czechoslovakia.

Neuroscience Letters

|June 27, 2009

Summary

Prolonged or strong interhemispheric stimulation can trigger spreading depression, a brain activity pattern. Stimulation parameters critically influence whether this leads to increased excitability or inhibitory patterns.

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Area of Science:

Neuroscience
Neurophysiology

Background:

Spreading depression is a wave of neuronal and glial depolarization that propagates across the cerebral cortex.
Understanding the factors that elicit and modulate spreading depression is crucial for neurological research.

Purpose of the Study:

To investigate the incidence and characteristics of spreading depression elicited by interhemispheric stimulation.
To determine the influence of stimulation parameters on the resulting neural activity patterns.

Main Methods:

Interhemispheric stimulation was applied to elicit spreading depression.
Variations in stimulus duration, pulse strength, and train length were systematically tested.
Neural responses, including field potentials and afterdischarges, were monitored.

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Main Results:

The incidence of spreading depression increased with prolonged stimulus duration, increased pulse strength, and longer stimulus trains.
Spreading depression occurred in one-third of initial trials and two-thirds with repeated stimulation.
Alternating interhemispheric responses and self-sustained afterdischarges often preceded spreading depression.
All phases of the interhemispheric response patterns exhibited inhibitory components.

Conclusions:

Stimulation parameters critically dictate whether a permanent increase in excitability (kindling) or inhibitory patterns emerge.
Interhemispheric stimulation can reliably elicit spreading depression, with its occurrence modulated by stimulus characteristics.