Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Distance Corrections01:15

Distance Corrections

To achieve precise distance measurements, especially in surveying and construction, certain corrections must be applied to account for potential sources of error like the standardization errors, temperature variations, and slope adjustments.Standardization error emerges when measurement equipment undergoes changes, such as wear, repairs, or weather impacts. To address this, surveyors compare the equipment’s readings to a standard. This process identifies any deviation that might lead to...
IR Spectrometers01:25

IR Spectrometers

There are two main infrared (IR) spectrophotometers: dispersive IR spectrometers and Fourier transform infrared (FTIR) spectrometers. In a dispersive IR spectrometer, a beam of infrared radiation produced by a hot wire is divided into two parallel equal-intensity beams using mirrors. One beam passes through the sample, while another is a reference beam. The beams then move through the monochromator, which separates the radiations into a continuous spectrum of different frequencies. The...
Computed Tomography01:10

Computed Tomography

Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
X-ray Imaging01:24

X-ray Imaging

German physicist Wilhelm Röntgen (1845–1923) was experimenting with electrical current when he discovered that a mysterious and invisible "ray" would pass through his flesh but leave an outline of his bones on a screen coated with a metal compound. In 1895, Röntgen made the first durable record of the internal parts of a living human: an "X-ray" image (as it came to be called) of his wife’s hand. Scientists worldwide quickly began their own experiments with X-rays, and by 1900, X-ray was widely...
Confocal Fluorescence Microscopy01:16

Confocal Fluorescence Microscopy

Confocal microscopy is an advanced microscopic technique. The prime advantage of the confocal microscope over other microscopy techniques is its ability to block the out-of-focus light from the illuminated samples using pinholes. It is widely used with fluorescence optics to obtain high-resolution, sharp contrast images. Unlike optical microscopes, confocal microscopes use a focused beam of light laser to scan the entire sample surface at different z-planes. These microscopes are, therefore,...
Deconvolution01:20

Deconvolution

Deconvolution, also known as inverse filtering, is the process of extracting the impulse response from known input and output signals. This technique is vital in scenarios where the system's characteristics are unknown, and they must be inferred from the observable signals.
Deconvolution involves several mathematical techniques to derive the impulse response. One common approach is polynomial division. In this method, the input and output sequences are treated as coefficients of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The presence of spontaneous echo contrast didn't increase the risk for left atrial appendage closure: A propensity score matching analysis based on the CLACBAC study.

Heliyon·2024
Same author

CD19 CAR-T treatment shows limited efficacy in r/r DLBCL with double expression and TP53 alterations.

Cytotherapy·2024
Same author

Omega-3 PUFAs slow organ aging through promoting energy metabolism.

Pharmacological research·2024
Same author

Immune-inflammatory markers and clinical characteristics as predictors of the depth of response and prognosis of patients with PD-L1 ≥50% metastatic non-small cell lung cancer receiving first-line immunotherapy.

Thoracic cancer·2024
Same author

Single-cell analysis of innate spinal cord regeneration identifies intersecting modes of neuronal repair.

Nature communications·2024
Same author

Heliox ventilation in elderly, hypertensive ICU patients improves microcirculation: A randomized controlled study.

Journal of critical care·2024
Same journal

Deep learning-based dose prediction to enhance planning efficiency in cervical brachytherapy with hybrid applicators.

Physics in medicine and biology·2026
Same journal

Corrigendum: Referenceless MR thermometry-a comparison of five methods (2017<i>Phys. Med. Biol</i>.<b>62</b>1-16).

Physics in medicine and biology·2026
Same journal

Corrigendum: Measured and Monte Carlo simulated electron backscatter to the monitor chamber for the varian TrueBeam linac (2016<i>Phys. Med. Biol</i>.<b>61</b>8779).

Physics in medicine and biology·2026
Same journal

Corrigendum: 3D range-modulator for scanned particle therapy: development, Monte Carlo simulations and experimental evaluation (2017<i>Phys. Med. Biol</i>.<b>62</b>7075).

Physics in medicine and biology·2026
Same journal

Recent progress in applications of computing to radiotherapy (ICCR 2016).

Physics in medicine and biology·2026
Same journal

Novel TMS coils designed using an inverse boundary element method.

Physics in medicine and biology·2026
See all related articles

Related Experiment Video

Updated: Jun 22, 2026

Multimodal Cross-Device and Marker-Free Co-Registration of Preclinical Imaging Modalities
07:13

Multimodal Cross-Device and Marker-Free Co-Registration of Preclinical Imaging Modalities

Published on: October 27, 2023

Collimator optimization in SPECT based on a joint detection and localization task.

Lili Zhou1, Gene Gindi

  • 1Department of Radiology, Stony Brook University, NY 11790, USA.

Physics in Medicine and Biology
|June 27, 2009
PubMed
Summary
This summary is machine-generated.

Optimizing Single Photon Emission Computed Tomography (SPECT) collimator design for joint signal detection and localization reveals that lower resolution and higher efficiency collimators are often optimal. This finding holds true across various localization tolerances.

More Related Videos

A Methodology for Capturing Joint Visual Attention Using Mobile Eye-Trackers
12:39

A Methodology for Capturing Joint Visual Attention Using Mobile Eye-Trackers

Published on: January 18, 2020

In Vivo Quantification of Hip Arthrokinematics during Dynamic Weight-bearing Activities using Dual Fluoroscopy
07:43

In Vivo Quantification of Hip Arthrokinematics during Dynamic Weight-bearing Activities using Dual Fluoroscopy

Published on: July 2, 2021

Related Experiment Videos

Last Updated: Jun 22, 2026

Multimodal Cross-Device and Marker-Free Co-Registration of Preclinical Imaging Modalities
07:13

Multimodal Cross-Device and Marker-Free Co-Registration of Preclinical Imaging Modalities

Published on: October 27, 2023

A Methodology for Capturing Joint Visual Attention Using Mobile Eye-Trackers
12:39

A Methodology for Capturing Joint Visual Attention Using Mobile Eye-Trackers

Published on: January 18, 2020

In Vivo Quantification of Hip Arthrokinematics during Dynamic Weight-bearing Activities using Dual Fluoroscopy
07:43

In Vivo Quantification of Hip Arthrokinematics during Dynamic Weight-bearing Activities using Dual Fluoroscopy

Published on: July 2, 2021

Area of Science:

  • Medical Imaging Physics
  • Nuclear Medicine Technology
  • Image Reconstruction and Analysis

Background:

  • The collimator in Single Photon Emission Computed Tomography (SPECT) is critical for balancing image noise and resolution.
  • Traditional collimator optimization often focuses on signal detection alone, not joint detection and localization.
  • Task-based criteria, using an ideal observer model, offer a framework for optimizing imaging system performance.

Purpose of the Study:

  • To investigate optimal SPECT collimator design for the more realistic task of joint signal detection and localization.
  • To evaluate the impact of localization requirements on collimator design choices.
  • To determine the influence of signal size and background noise on optimal collimator parameters.

Main Methods:

  • Utilized an ideal observer model operating on sinogram data to define optimal task performance.
  • Evaluated a range of parallel-hole, low-energy collimators with varying resolution and efficiency.
  • Simulated 2D objects with background variability noise and photon noise in the sinogram data.

Main Results:

  • Optimal collimator design for joint detection and localization favors lower resolution and higher efficiency compared to commercial standards.
  • The optimal design proved insensitive to the specified localization tolerance radius.
  • Increasing signal size degraded optimal collimator resolution, while increasing background noise improved it.

Conclusions:

  • For the studied scenario, incorporating a localization task does not alter the optimal collimator design compared to detection-only tasks.
  • The findings suggest a trade-off favoring efficiency over resolution for improved joint detection and localization in SPECT.
  • Signal size and background noise levels are significant factors influencing the optimal balance between collimator resolution and efficiency.