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Related Experiment Videos

High-level gentamicin resistance in Enterococcus faecalis bacteremia.

G A Noskin1, M Till, B K Patterson

  • 1Department of Medicine, (Division of Infectious Diseases), Northwestern University Medical School, Chicago, Illinois 60611.

The Journal of Infectious Diseases
|December 1, 1991
PubMed
Summary

High-level gentamicin resistance (GRE) in Enterococcus faecalis bacteremia is linked to worse outcomes, especially in specific patient groups. GRE may diminish antibiotic effectiveness and impact survival rates in certain E. faecalis infections.

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Area of Science:

  • Infectious Diseases
  • Clinical Microbiology
  • Antimicrobial Resistance

Background:

  • Enterococcus faecalis is a common cause of hospital-acquired infections.
  • High-level gentamicin resistance (GRE) in E. faecalis complicates treatment options.
  • Understanding the clinical impact of GRE is crucial for patient management.

Purpose of the Study:

  • To compare outcomes in patients with E. faecalis bacteremia with and without GRE.
  • To identify factors associated with mortality in E. faecalis bacteremia.
  • To assess the effect of GRE on patient survival and antibiotic response.

Main Methods:

  • Retrospective analysis of patients with E. faecalis bacteremia.
  • Comparison of clinical characteristics and outcomes between GRE-positive and GRE-negative groups.

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  • Statistical analysis to determine factors associated with mortality.

    • Main Results:

    • GRE bacteremia was associated with higher rates of nosocomial acquisition, bladder catheterization, and prior cephalosporin use.
    • Overall mortality was linked to septic shock, high-risk sources, and polymicrobial bacteremia.
    • While not statistically significant, GRE bacteremia showed higher mortality (47% vs. 37%), particularly in monomicrobial, low-risk source infections.

    Conclusions:

    • High-level gentamicin resistance may adversely affect survival in E. faecalis bacteremia, especially in low-risk scenarios.
    • GRE might diminish the effectiveness of antibiotic therapy.
    • Further research is needed to fully elucidate the impact of GRE on E. faecalis infections.