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Multicenter validation of the magnetic resonance T2* technique for segmental and global quantification of myocardial
Anna Ramazzotti1, Alessia Pepe, Vincenzo Positano
1MRI Laboratory, G Monasterio Foundation and Institute of Clinical Physiology, Pisa, Italy.
Purpose:
To assess the transferability of the magnetic resonance imaging (MRI) multislice multiecho T2(*) technique for global and segmental measurement of iron overload in thalassemia patients.
Materials And Methods:
Multiecho T2(*) sequences were installed on six MRI scanners. Five healthy subjects (n = 30) were scanned at each site; five thalassemia major (TM) patients were scanned at the reference site and were rescanned locally (n = 25) within 1 month. T2(*) images were analyzed using previously validated software.
Results:
T2(*) values of healthy subjects showed intersite homogeneity. On TM patients, for global heart T2(*) values the correlation coefficient was 0.97, coefficients of variation (CoV(s)) ranged from 0.04-0.12, and intraclass coefficients (ICC(s)) ranged from 0.94-0.99. The mean CoV and ICC for segmental T2(*) distribution were 0.198 and 88, respectively.
Conclusion:
The multislice multiecho T2(*) technique is transferable among scanners with good reproducibility.
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