Related Experiment Video
Updated: Jun 22, 2026
Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking
Published on: February 12, 2011
Persistent decline in longitudinal and radial strain after coronary microembolization detected on velocity encoded
Demetrius L Dicks1, Marcus Carlsson, Einar Heiberg
1Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California 94143-2205, USA.
Purpose:
To use velocity-encoded phase contrast (PC) MRI in assessing the effect of coronary microembolization on longitudinal and radial myocardial strain.
Materials And Methods:
A combined X-ray and MR system (XMR) was used for selective left anterior descending artery catheterization and microinfarct assessment in swine (n = 6). The embolized area at risk was defined on perfusion MRI followed by administration of a 7500 count (size = 100-300 microm) of the embolic agent. Quantification of strain and microinfarction was performed at 1 h and 1 week using PC-MRI and delayed enhancement (DE) MRI, respectively. At postmortem, sliced hearts were stained to define microinfarction.
Results:
Baseline longitudinal and radial strain did not differ between area-at-risk and remote myocardium. The embolized territory (area at risk) showed significant decline in longitudinal strain from -11.5 +/- 3.2% to 1.8 +/- 2.5% at 1 h (P < 0.05) and -3.9 +/- 1.1% at 1 week (P < 0.05). Similarly, regional radial strain progressively declined from 23.6 +/- 2.5% at baseline to 12.5 +/- 3.7% at 1 h (P < 0.05) and 4.8 +/- 5.0% at 1 week (P < 0.01). The size of microinfarction was not significantly different between DE-MRI and histochemical staining.
Conclusion:
PC-MRI is sensitive in assessing changes in regional longitudinal and radial strain after coronary embolization. Longitudinal and radial strain of the hyperenhanced patchy microinfarction demonstrates persistent decline over the course of 1 week.
Insights
Phase contrast MRI effectively measures changes in myocardial strain after coronary microembolization. Both longitudinal and radial strain show a persistent decline in the week following the procedure.
Area of Science:
- Cardiovascular Imaging
- Myocardial Mechanics
- Interventional Cardiology
Background:
- Coronary microembolization can impair myocardial function.
- Assessing microinfarcts and their functional impact is crucial for understanding cardiac injury.
- Non-invasive imaging techniques are needed to evaluate these changes.
Purpose of the Study:
- To evaluate the efficacy of velocity-encoded phase contrast (PC) MRI in quantifying myocardial strain alterations following coronary microembolization.
- To assess the longitudinal and radial strain changes in the affected myocardium.
Main Methods:
- Utilized a combined X-ray and MR (XMR) system for selective coronary catheterization and microembolization in swine.
- Quantified myocardial strain using PC-MRI and microinfarction with delayed enhancement (DE) MRI at 1 hour and 1 week post-embolization.
- Correlated MRI findings with postmortem histochemical staining for microinfarction.
Main Results:
- Coronary microembolization significantly reduced both longitudinal and radial myocardial strain in the area at risk.
- Longitudinal strain decreased from -11.5% at baseline to 1.8% at 1 hour and -3.9% at 1 week.
- Radial strain decreased from 23.6% at baseline to 12.5% at 1 hour and 4.8% at 1 week.
- DE-MRI accurately identified microinfarction size compared to histology.
Conclusions:
- Velocity-encoded PC-MRI is a sensitive tool for detecting regional myocardial strain changes after coronary embolization.
- Persistent decline in longitudinal and radial strain is observed in microinfarcted regions over a 1-week period.
More Related Videos
11:50High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart
Published on: July 9, 2010
09:05Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation
Published on: October 20, 2016