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The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...

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Updated: Jun 22, 2026

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

[The interactions between the circadian clock and aging].

Jia-Li Gu¹, Tao Wu, Hong-Fei Tong

¹College of Jian Xing, Zhejiang University of Technology, Hangzhou 310032, China.

Sheng Li Ke Xue Jin Zhan [Progress in Physiology]

|June 30, 2009

Summary

This summary is machine-generated.

Organisms have internal circadian clocks that regulate daily rhythms. Aging disrupts these clocks, and disorganized circadian rhythms accelerate the aging process, impacting overall health.

Related Experiment Videos

Last Updated: Jun 22, 2026

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

Area of Science:

Chronobiology
Gerontology
Molecular Biology

Context:

Circadian rhythms are fundamental to organismal physiology and behavior.
The internal circadian clock comprises a master clock (suprachiasmatic nucleus) and peripheral clocks.
Aging significantly alters circadian rhythm parameters like amplitude, period, and phase.

Purpose:

To review recent advancements in understanding the interplay between the circadian clock and aging.
To explore how circadian rhythm disruption influences the aging process.
To provide insights into the mechanisms underlying aging and its effects on organisms.

Summary:

Circadian rhythms, controlled by the internal circadian clock, are altered with aging.
Disorganization of circadian rhythms accelerates aging.
This review examines the bidirectional relationship between circadian clocks and aging.

Impact:

Enhances understanding of aging mechanisms.
Highlights the role of circadian health in organismal aging.
Provides a basis for future research into age-related disorders and interventions.