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Updated: Jun 22, 2026

X-Ray Crystallography to Study the Oligomeric State Transition of the Thermotoga maritima M42 Aminopeptidase TmPep1050
Published on: May 13, 2020
First structural insights into the TpsB/Omp85 superfamily
Françoise Jacob-Dubuisson1, Vincent Villeret, Bernard Clantin
1INSERM U629, Institut Pasteur de Lille, 1 rue Calmette, F-59019 Lille cedex, France. francoise.jacob@ibl.fr
Abstract:
Proteins of the TpsB/Omp85 superfamily are involved in protein transport across, or assembly into, the outer membrane of Gram-negative bacteria, and their distant eukaryotic relatives exert similar functions in chloroplasts and mitochondria. The X-ray structure of one TpsB transporter, FhaC, provides the bases to decipher the mechanisms of action of these proteins. With two POTRA domains in the periplasm, a transmembrane beta barrel and a large loop harboring a functionally important motif, FhaC epitomizes the conserved features of the super-family.
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