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Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Drugs that Stabilize Microtubules01:15

Drugs that Stabilize Microtubules

Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...

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Related Experiment Video

Updated: Jun 22, 2026

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro
08:04

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro

Published on: March 18, 2014

Pharmacotherapy of sarcoma.

Rashmi Chugh1, Laurence H Baker

  • 1University of Michigan, C407 Med Inn Building, 1500 E. Medical Center Dr, SPC 5848, Ann Arbor, MI 48109-5848, USA. rashmim@umich.edu

Expert Opinion on Pharmacotherapy
|June 30, 2009
PubMed
Summary

This review covers therapeutic agents for bone and soft-tissue sarcomas. Chemotherapy has improved outcomes for some sarcomas, but new strategies are needed for most patients.

Area of Science:

  • Oncology
  • Medical Therapeutics

Background:

  • Sarcomas are rare cancers (<1% adult, 12% pediatric malignancies) originating from connective tissues.
  • Over 50 histologic subtypes exhibit significant heterogeneity, necessitating tailored therapeutic approaches.
  • Variable responsiveness to treatment underscores the need for diverse management strategies.

Purpose of the Study:

  • To review therapeutic agents used in managing bone and soft-tissue sarcomas.
  • To provide an overview of current treatment modalities for sarcoma patients.

Main Methods:

  • Literature search of major conference proceedings.
  • Utilized PubMed search engine for relevant studies.
  • Systematic review of therapeutic strategies in sarcoma management.

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Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
09:25

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

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Last Updated: Jun 22, 2026

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro
08:04

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro

Published on: March 18, 2014

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
09:25

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

Main Results:

  • Chemotherapy has demonstrated improved outcomes in specific bone sarcomas and gastrointestinal stromal tumors.
  • Current therapeutic advancements have benefited certain sarcoma subtypes.

Conclusions:

  • While chemotherapy offers benefits for some, it is insufficient for the majority of sarcoma patients.
  • Additional therapeutic strategies are crucial for improving overall sarcoma patient outcomes.
  • The heterogeneity of sarcomas demands ongoing research into novel treatment modalities.