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Toxicological analysis of a fatal baclofen (Lioresal) ingestion
A D Fraser1, W MacNeil, A F Isner
1Toxicology Laboratory, Victoria General Hospital, Nova Scotia, Canada.
Journal of Forensic Sciences
|September 1, 1991
Abstract:
A fatality following ingestion of the drug baclofen (Lioresal) is described. Baclofen was identified in urine by gas chromatography/mass spectrometry. After derivatization with trinitrobenzene sulfonic acid, baclofen was quantitated in serum and urine by high-performance liquid chromatography. The concentration of baclofen was 17 mg/L in serum and 760 mg/L in urine collected approximately 12 h after the overdose. To our knowledge, this is only the second reported fatality involving a baclofen overdose. The previous case did not include quantitation of baclofen in any biological fluid.