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Updated: Jun 22, 2026
Creation and Transplantation of an Adipose-derived Stem Cell (ASC) Sheet in a Diabetic Wound-healing Model
Published on: August 4, 2017
Early translation of adipose-derived cell therapy for cardiovascular disease
Ricardo Sanz-Ruiz1, Eugenia Fernández-Santos, Marta Domínguez-Muñoa
1Cardiology Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Abstract:
Over the past decade, cell therapy has emerged as a new approach to reversing myocardial ischemia. Several types of adult stem cells have been studied in both preclinical and clinical conditions for this purpose: bone marrow cells, circulating cells, and myoblasts. Nevertheless, the quest for the ideal "anti-ischemic" cell is still ongoing. Recently, the existence of a population of stem cells located in adipose tissue (adipose-derived stem cells) has been observed. These are able to differentiate into multiple cell lineages including cardiomyocytic differentiation. In this review we discuss the basic principles of adipose-derived stem cells (types and characteristics, harvesting, and expansion), the initial experimental studies, and the currently ongoing clinical trials.
Insights
Adipose-derived stem cells show promise for treating myocardial ischemia. These cells can differentiate into heart cells, advancing cell therapy research for cardiac repair.
Area of Science:
- Regenerative Medicine
- Cardiovascular Research
- Stem Cell Biology
Background:
- Cell therapy is a developing strategy for myocardial ischemia.
- Adult stem cells like bone marrow cells and myoblasts have been investigated.
- The search for optimal anti-ischemic cells continues.
Purpose of the Study:
- To review adipose-derived stem cells (ASCs) for myocardial ischemia.
- To discuss ASCs' potential for cardiomyocytic differentiation.
- To cover basic principles, experimental studies, and clinical trials of ASCs.
Main Methods:
- Review of preclinical and clinical studies on stem cell therapy for myocardial ischemia.
- Focus on adipose-derived stem cells (ASCs).
- Discussion of ASC characteristics, isolation, expansion, and differentiation potential.
Main Results:
- Adipose-derived stem cells possess multipotent differentiation capabilities, including cardiomyocytic potential.
- ASCs represent a promising cell source for regenerative therapy in ischemic heart disease.
- Ongoing clinical trials are evaluating the efficacy of ASCs.
Conclusions:
- Adipose-derived stem cells are a viable candidate for cell-based therapy in myocardial ischemia.
- Further research and clinical evaluation are essential to establish ASCs as a standard treatment.
- ASCs offer a promising avenue for cardiac repair and regeneration.
