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Bisbenzylisoquinoline alkaloids.

P L Schiff1

  • 1Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pennsylvania 15261.

Journal of Natural Products
|May 11, 1991
PubMed
Summary
This summary is machine-generated.

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This review summarizes new bisbenzylisoquinoline alkaloids discovered between 1986-1989, detailing their sources, properties, and effects. It also covers isolation techniques and biosynthesis for these phenylalanine-derived compounds.

Area of Science:

  • Natural Product Chemistry
  • Pharmacology
  • Organic Chemistry

Background:

  • Bisbenzylisoquinoline alkaloids are a significant class of phenylalanine-derived metabolites.
  • These compounds exhibit diverse chemical structures and pharmacological activities.
  • A substantial number of new alkaloids were identified in the late 20th century.

Purpose of the Study:

  • To provide a comprehensive tabular review of bisbenzylisoquinoline alkaloids.
  • To document new alkaloids isolated from 1986-1989.
  • To compile data on botanical sources, physicochemical properties, spectral data, and pharmacological activities.

Main Methods:

  • Literature review of scientific publications from 1986-1989.
  • Compilation and organization of data on isolated alkaloids.

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  • Inclusion of data on previously identified alkaloids for comparison.

    • Main Results:

    • Detailed information on approximately 122 new bisbenzylisoquinoline alkaloids.
    • Inclusion of botanical sources, physicochemical and spectral data for new and existing alkaloids.
    • Summary of pharmacological activities for a wide range of these compounds.

    Conclusions:

    • The period 1986-1989 saw significant advancements in the discovery and characterization of bisbenzylisoquinoline alkaloids.
    • This review serves as a valuable resource for researchers in natural product chemistry and pharmacology.
    • The compilation facilitates further research into the biosynthesis, synthesis, and therapeutic potential of these alkaloids.