Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Exon Recombination02:32

Exon Recombination

The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
Exon shuffling follows “splice frame rules.” Each exon has three reading...
Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
Organization of Genes02:07

Organization of Genes

Overview

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Human Left Ventricle circRNA-miRNA-mRNA Network Analyses Reveal a Novel Proangiogenic Role for circNPHP1 Under Ischemic Conditions.

JACC. Basic to translational science·2026
Same author

Listening to learn: translating qualitative insights from adults with congenital heart disease and heart failure into patient-centered care.

European heart journal. Quality of care & clinical outcomes·2025
Same author

Advancing patient-centred care in complex congenital heart disease: the need for disease-specific long-term health-related quality of life tools.

European journal of cardiovascular nursing·2025
Same author

Prediction of miRNA Targets in Plants.

Methods in molecular biology (Clifton, N.J.)·2025
Same author

Bifurcation and stability analysis of within host HIV dynamics with multiple infections and intracellular delay.

Chaos (Woodbury, N.Y.)·2025
Same author

Cell state-dependent allelic effects and contextual Mendelian randomization analysis for human brain phenotypes.

Nature genetics·2025

Related Experiment Video

Updated: Jun 22, 2026

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
06:41

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

Human intronless disease associated genes are slowly evolving.

Subhash Mohan Agarwal1, Prashant K Srivastava

  • 1Center for Computational Biology and Bioinformatics, School of Information Technology, Jawaharlal Nehru University, New Delhi 110067, India. smagarwal@yahoo.com

BMB Reports
|June 30, 2009
PubMed
Summary

Human disease-associated intronless genes show distinct evolutionary patterns and localized expression, suggesting specific selective pressures and essential roles in development. These findings aid in identifying such genes.

More Related Videos

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

Related Experiment Videos

Last Updated: Jun 22, 2026

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
06:41

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

Area of Science:

  • Genomics
  • Evolutionary Biology
  • Molecular Biology

Background:

  • Intronless genes, lacking introns, represent a unique class of genetic elements.
  • Understanding their evolutionary and functional attributes is crucial for deciphering disease mechanisms.

Purpose of the Study:

  • To investigate the evolutionary and functional characteristics of human-mouse homologous intronless disease and non-disease genes.
  • To explore sequence conservation, tissue expression, and functional composition.
  • To understand the selective pressures acting on these genes.

Main Methods:

  • Comparative analysis of human-mouse homologous intronless genes.
  • Assessment of sequence conservation (Ka, Ks ratios).
  • Analysis of tissue expression patterns, domain composition, and Gene Ontology (GO) terms.

Main Results:

  • Disease-associated intronless genes exhibit significantly lower Ka and Ka/Ks ratios, indicating stronger purifying selection.
  • These genes primarily show homology within eukaryotic genomes and have localized expression patterns.
  • Different classes of intronless disease genes display diverse selective pressures and are enriched for high-level developmental functions.

Conclusions:

  • Intronless disease genes are under distinct evolutionary constraints compared to non-disease genes.
  • Their localized expression and enrichment for developmental functions highlight their importance in complex organisms.
  • These insights can improve the identification of novel disease-related intronless genes.