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Related Experiment Videos

Cocaine-related vascular headaches.

A Dhuna1, A Pascual-Leone, M Belgrade

  • 1Department of Neurology, Hennepin County Medical Center, Minneapolis, MN.

Journal of Neurology, Neurosurgery, and Psychiatry
|September 1, 1991
PubMed
Summary

Cocaine intoxication can cause acute headaches with migraine features. These headaches, often without complications, may stem from cocaine

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Area of Science:

  • Neurology
  • Toxicology

Background:

  • Cocaine use is associated with various medical complications.
  • Headaches are a common symptom reported by individuals using cocaine.

Observation:

  • Reviewed records of 21 patients hospitalized for acute headache and cocaine intoxication (Jan 1985-Dec 1988).
  • Identified 15 patients with migrainous headaches, excluding neurological/systemic complications.
  • These patients lacked prior headache history or family history of migraine, and all recovered favorably.

Findings:

  • Cocaine-induced headaches can present with migrainous features.
  • Possible mechanisms include sympathomimetic/vasoconstrictive effects during intoxication.
  • Headaches during withdrawal or binges may involve alterations in the serotonergic system.

Implications:

  • Understanding cocaine's impact on vascular and neurological systems is crucial.
  • Highlights the need for recognizing and managing cocaine-related headaches.
  • Suggests distinct pathophysiological pathways for headaches related to cocaine use, withdrawal, and binge patterns.

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