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Disruption of the OCH1 and MNN1 genes decrease N-glycosylation on glycoprotein expressed in Kluyveromyces lactis

Bo Liu1, Xin Gong, Shaohong Chang

  • 1Department of Microorganism Engineering, Beijing Institute of Biotechnology, 20 Dongdajie Street, Fengtai District, Beijing 100071, China.

Journal of Biotechnology
|June 30, 2009
PubMed
Summary

Researchers engineered Kluyveromyces lactis yeast to produce therapeutic glycoproteins without non-human hypermannosylation. This modification improves protein properties for medical applications by reducing mannose residues on N-linked oligosaccharides.

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