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Enaminones 10. Molecular modeling aspects of the 5-methylcyclohexenone derivatives
Ainsley Gibson1, John Harkless, Mariano Alexander
1Department of University Informational Services, Georgetown University, Washington, DC 20057, United States.
Abstract:
This article expands upon our original submission to the Eddington, N. D.; Cox, D. S.; Khurana, M.; Salama, N. N.; Stables, J. P.; Harrison, S. J.; Negussie, A.; Taylor, R. S.; Tran, U. Q.; Moore, J. A.; Barrow, J. C.; Scott, K. R. Eur. J. Med. Chem.2003, 38, 49 on a series of twenty (20) compounds, all 5-methyl-3-[(substituted)-phenylamino]-cyclohex-2-enone derivatives. This article provides the reasons why the compounds are active/inactive. By use of computational methods, the reasons for activity/inactivity are explained.
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