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Pancytopenia with hypercellular bone marrow secondary to cytomegalovirus after cardiac transplant

Osama Elkhateeb1, Simon Jackson, Walter F Schlech

  • 1Division of Cardiology, Dalhousie University, Halifax, Nova Scotia.

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
|June 30, 2009
PubMed

We describe a case of cytomegalovirus-induced pancytopenia in a heart transplant patient. The interesting finding of a hypercellular bone marrow indicates the possibility of a different mechanism for the pancytopenia other than bone marrow suppression. The patient was treated with ganciclovir, which resulted in the complete resolution of the viremia and pancytopenia. Cytomegalovirus infection should be suspected in heart transplant patients with pancytopenia, regardless of bone marrow results. The pathogenesis of cytomegalovirus-induced pancytopenia is likely multifactorial, with both a central and peripheral effect.

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