Controlled drug release from multilayered phospholipid polymer hydrogel on titanium alloy surface

Area of Science:

• Biomaterials Science
• Polymer Chemistry
• Drug Delivery Systems

Background:

• Titanium (Ti) alloys are widely used in biomedical implants.
• Controlling drug release from implantable materials is crucial for therapeutic efficacy.
• Developing novel drug delivery systems with tunable release profiles remains a significant challenge.

Purpose of the Study:

• To develop a multilayered hydrogel system for controlled release of the antineoplastic agent paclitaxel (PTX).
• To functionalize a Ti alloy surface with a PTX-loaded hydrogel using layer-by-layer (LbL) self-assembly.
• To investigate the influence of PTX loading location on its release kinetics.

Main Methods:

• Synthesis of a multilayered hydrogel via LbL self-assembly using phospholipid polymer (PMBV) and poly(vinyl alcohol) (PVA).
• Incorporation of paclitaxel (PTX) into the PMBV layers due to its amphiphilic nature.
• In vitro evaluation of PTX release profiles based on its location within the hydrogel structure.

Main Results:

• Successful fabrication of multilayered hydrogels on a Ti alloy surface.
• PTX loading capacity increased with the number of layers, with higher concentration in PMBV layers.
• In vitro studies confirmed that the location of PTX within the hydrogel dictates its release start and profile.
• The LbL technique allows for precise control over PTX localization and release.

Conclusions:

• LbL self-assembly provides a facile method for creating PTX-loaded multilayered hydrogels.
• The precise control over PTX location enables tunable drug release kinetics.
• This approach holds promise for advanced applications in biomedicine and pharmaceutics, particularly for drug-eluting implants.