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Intracranial infiltration by recurrent scalp dermatofibrosarcoma protuberans
Tatsuya Abe1, Tohru Kamida, Makoto Goda
1Department of Neurosurgery, Oita University School of Medicine, Idaigaoka 1-1, Hasama, Yufu, Oita 879-5593, Japan. abet@med.oita-u.ac.jp
Summary
Dermatofibrosarcoma protuberans (DFSP) is a rare scalp sarcoma. This case highlights DFSP
Area of Science:
- Oncology
- Neurosurgery
- Dermatology
Background:
- Dermatofibrosarcoma protuberans (DFSP) is a rare, slow-growing soft tissue sarcoma.
- DFSP typically affects the dermis and subcutaneous tissue, rarely involving the central nervous system.
Observation:
- A 22-year-old male with a history of scalp DFSP presented with new neurological symptoms.
- MRI revealed a large frontoparietal mass consistent with DFSP recurrence.
- The tumor abutted and invaded the adjacent brain cortex and extended along Virchow-Robin spaces.
Findings:
- Despite macroscopically complete surgical removal, the patient experienced multiple recurrences.
- Histopathological analysis confirmed DFSP with extensive infiltration into brain tissue.
- The tumor demonstrated high infiltrative characteristics along neurovascular pathways.
Implications:
- Standard treatments (surgery, radiotherapy, chemotherapy) showed limited efficacy in preventing recurrence.
- The infiltrative nature of DFSP necessitates novel therapeutic strategies.
- Molecular-targeted agents may offer a more effective approach for managing aggressive DFSP with CNS involvement.
