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Biochemical Reconstitution of Steroid Receptor•Hsp90 Protein Complexes and Reactivation of Ligand Binding
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Nestin modulates glucocorticoid receptor function by cytoplasmic anchoring.

Rudolph Reimer1, Heike Helmbold, Beata Szalay

  • 1Heinrich-Pette-Institute for Experimental Virology and Immunology at the University of Hamburg, Hamburg, Germany.

Plos One
|June 30, 2009
PubMed
Summary

Nestin and vimentin intermediate filaments anchor the glucocorticoid receptor (GR) in progenitor cells. This anchoring is crucial for GR-mediated growth suppression, with nestin regulating GR

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