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Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library
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The azido acid approach to beta-peptides: parallel synthesis of a tri-beta-peptide library by fluorous tagging

Xiao Wang1, Scott G Nelson, Dennis P Curran

  • 1Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260 USA.

Tetrahedron
|June 30, 2009
PubMed

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Proteins are involved in several cellular processes and biochemical reactions. Analyzing a specific protein of interest requires it to be isolated from the other proteins in the cell. This is achieved by overexpressing the specific gene in a suitable host to produce large quantities of the target protein. A tag or label is recombined with the gene to produce a fusion protein containing the target protein and the tag. The tags on these fusion proteins can then be used for easy detection and...