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Related Experiment Video

Updated: Jun 22, 2026

Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-(phosphinetriyl)tripiperidine]}palladium Under Mild Reaction Conditions

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Published on: March 20, 2014

A dipalladium complex with a single hydroxo bridge and its methylpalladium precursor.

Lingyun Cao¹, Michael C Jennings, Richard J Puddephatt

¹Department of Chemistry, University of Western Ontario, London, CanadaN6A 5B7.

Dalton Transactions (Cambridge, England : 2003)

|June 30, 2009

Summary

Researchers synthesized a novel methylpalladium complex, [PdMe(bpma)]Cl, and converted it to a hydroxo-bridged dinuclear palladium complex, [Pd2(micro-OH)(bpma)2](OTf)3. This complex models hydrolysis products of biologically active platinum compounds.

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Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-(phosphinetriyl)tripiperidine]}palladium Under Mild Reaction Conditions

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Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions

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Ligand-Mediated Nucleation and Growth of Palladium Metal Nanoparticles

Ligand-Mediated Nucleation and Growth of Palladium Metal Nanoparticles

Published on: June 25, 2018

Area of Science:

Organometallic Chemistry
Coordination Chemistry
Catalysis

Background:

Palladium complexes are crucial in catalysis and medicinal chemistry.
Understanding hydrolysis pathways of metal-based drugs like cisplatin is important for drug development.
Dinuclear metal complexes with bridging ligands offer unique structural and reactivity insights.

Purpose of the Study:

To synthesize and characterize a novel methylpalladium complex.
To investigate the reactivity of the methylpalladium complex towards Lewis acids and Brønsted acids.
To explore the formation and structural features of a hydroxo-bridged dinuclear palladium complex as a model for biological hydrolysis.

Main Methods:

Reaction of [PdClMe(Me2NCH2CH2NMe2)] with bis(2-pyridylmethyl)amine (bpma).
Anion exchange reactions using silver triflate (AgOTf) or silver tetrafluoroborate (AgBF4).
Reaction with B(C6F5)3 or HOTf to form the dinuclear complex.
Structural characterization of the resulting complexes.

Main Results:

Synthesis of the methylpalladium complex [PdMe(bpma)]Cl.
Conversion to triflate and tetrafluoroborate salts.
Formation of the hydroxo-bridged dinuclear palladium complex [Pd2(micro-OH)(bpma)2](OTf)3.
Structural determination revealed an unusually large Pd-O-Pd angle of 141.2(3) degrees.

Conclusions:

A novel hydroxo-bridged dinuclear palladium complex was successfully synthesized and characterized.
The complex exhibits a unique structural feature with a large Pd-O-Pd angle.
This complex serves as a valuable model for understanding the hydrolysis of biologically active metal compounds, including platinum-based drugs.