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Related Experiment Video

Updated: Jun 22, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

[Large vessel vasculitis].

L Caspary¹, S Schellong

¹Angiologische Praxis Luisenstrasse und Klinikum Oststadt-Heidehaus, Luisenstrasse 10/11, Hannover, Germany. LCaspary@t-online.de

|June 30, 2009

Summary

This summary is machine-generated.

Large vessel vasculitis involves inflammation of the aorta and its branches, potentially causing blockages or aneurysms. Early detection and treatment with corticosteroids and methotrexate are key for managing giant cell arteritis (GCA).

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Mouse Models for Graft Arteriosclerosis

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Last Updated: Jun 22, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

Mouse Models for Graft Arteriosclerosis

Mouse Models for Graft Arteriosclerosis

Published on: May 14, 2013

Area of Science:

Cardiovascular Medicine
Rheumatology
Immunology

Context:

Large vessel vasculitis affects the aorta and its branches, leading to stenosis, occlusion, or aneurysms.
Giant cells are a characteristic finding in this inflammatory condition.
Advancements in vascular imaging (ultrasound, MRI, PET) improve early detection of Takayasu arteritis and GCA.

Purpose:

To summarize the characteristics, diagnosis, and management of large vessel vasculitis, particularly giant cell arteritis (GCA).
To highlight recent advances in vascular imaging for earlier diagnosis.
To describe a specific subtype of GCA affecting predominantly younger females.

Summary:

Giant cell arteritis (GCA) is a form of large vessel vasculitis characterized by inflammation of the aorta and its branches.
A subtype of GCA, often seen in younger females without cranial symptoms, presents with obstructions in arm vessels or the aorta.
Initial treatment involves corticosteroids, with methotrexate as an additional immunosuppressive option. Disease activity requires monitoring via lab tests and imaging.

Impact:

Improved understanding of GCA subtypes and their clinical presentation.
Enhanced diagnostic capabilities through advanced vascular imaging techniques.
Guidance on therapeutic strategies, including corticosteroids and methotrexate, for managing GCA.