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Related Concept Videos

Antiasthma Drugs: Leukotriene Modifiers01:19

Antiasthma Drugs: Leukotriene Modifiers

Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-IV: Nursing Management01:30

Asthma-IV: Nursing Management

The nursing management of asthma is a comprehensive approach that relies heavily on the expertise and dedication of healthcare professionals. It involves thorough assessment, accurate diagnosis, strategic planning, effective implementation, and diligent evaluation. By meticulously following this step-by-step process, healthcare professionals play a crucial role in providing the best possible care and treatment for patients with asthma, enhancing their overall health and well-being.
First, in...
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

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Updated: Jun 22, 2026

Methodology for Sputum Induction and Laboratory Processing
13:28

Methodology for Sputum Induction and Laboratory Processing

Published on: December 17, 2017

Montelukast in guidelines and beyond.

Jean Bousquet1, Pascal Demoly, Marc Humbert

  • 1Service des Maladies Respiratoires, Hôpital Arnaud de Villeneuve, 371 avenue Doyen Gaston Giraud, 34275 Montpellier, Cedex 5, France. jean.bousquet@inserm.fr

Advances in Therapy
|June 30, 2009
PubMed
Summary
This summary is machine-generated.

Leukotriene modifiers, like montelukast, are essential preventive treatments for persistent asthma across all age groups. This review examines montelukast

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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

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Methodology for Sputum Induction and Laboratory Processing
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Published on: December 17, 2017

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Area of Science:

  • Pulmonology
  • Allergology
  • Pharmacology

Background:

  • Preventive anti-inflammatory treatment is crucial for persistent asthma.
  • Inhaled corticosteroids are primary, but other options exist for mild or add-on therapy.
  • Leukotriene modifiers are the sole validated preventive treatment for all ages.

Purpose of the Study:

  • To review the role of montelukast, a leukotriene receptor antagonist, in asthma management.
  • To evaluate montelukast's place based on major asthma and rhinitis guidelines.
  • To incorporate recent studies not yet included in existing guidelines.

Main Methods:

  • Systematic review of major asthma guidelines: NAEPP, British Guideline, GINA.
  • Inclusion of Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines.
  • Analysis of new research data on leukotriene modifiers.

Main Results:

  • Montelukast is a validated preventive treatment for persistent asthma in all age groups.
  • Guidelines consistently recommend leukotriene modifiers as monotherapy or add-on treatment.
  • New studies support montelukast's efficacy and safety profile.

Conclusions:

  • Montelukast holds a significant place in asthma management as a preventive therapy.
  • It offers a valuable option for patients with mild asthma or as add-on therapy.
  • Further research and guideline updates are warranted to reflect new evidence.