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Related Experiment Video

Updated: Jun 22, 2026

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation

Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation

Published on: March 14, 2017

Parathyroid hormone-dependent hypercalcemia.

Judit Toke¹, Attila Patócs, Katalin Balogh

¹2nd Department of Medicine, Semmelweis University, Budapest, Hungary.

Wiener Klinische Wochenschrift

|June 30, 2009

Summary

Recent advancements enhance understanding of parathyroid hormone-dependent hypercalcemic disorders. This review covers sporadic and familial forms, including genetic syndromes and patient data.

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Area of Science:

Endocrinology
Genetics
Internal Medicine

Background:

Significant progress in understanding hypercalcemic disorders over the past 15 years.
Focus on parathyroid hormone-dependent etiologies, both sporadic and familial.
Hereditary hypercalcemic disorders include several well-defined genetic syndromes.

Purpose of the Study:

To review key advancements in sporadic and hereditary hypercalcemic disorders.
To emphasize specific familial syndromes like MEN1, MEN2A, HJT, FIH, FHH, and NS-HPTH.
To present clinical characteristics of patients diagnosed with these disorders.

Main Methods:

Literature review of recent findings on hypercalcemic disorders.
Focus on parathyroid hormone-dependent conditions.
Clinical data analysis of 141 patients from a Hungarian endocrine center (1997-2007).

Main Results:

Identification and characterization of 141 patients with parathyroid hormone-dependent hypercalcemia.
Inclusion of index patients from 18 families with hereditary disorders.
Consolidation of clinical data for sporadic and familial hypercalcemic conditions.

Conclusions:

Enhanced understanding of the pathogenesis and pathophysiology of hypercalcemic disorders.
Clinical data provides insights into the presentation of these rare conditions.
Highlights the importance of recognizing both sporadic and hereditary forms for accurate diagnosis and management.