Related Experiment Video
Updated: Jun 22, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
Published on: February 26, 2013
Epidemiology of atrial fibrillation
D Conen1, S Osswald, C M Albert
1Department of Medicine, Cardiology Division, University Hospital, Basel, Switzerland. conend@uhbs.ch
Insights
Atrial fibrillation (AF) is common, but treatments are risky. Modifiable risk factors like blood pressure, obesity, and inflammation are key to preventing AF and improving patient outcomes.
Area of Science:
- Cardiology
- Preventive Medicine
- Epidemiology
Background:
- Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia.
- Current AF elimination strategies have limited long-term success and carry significant risks.
Purpose of the Study:
- To review current evidence on treatable risk factors for atrial fibrillation.
- To identify areas requiring further research in AF pathogenesis and prevention.
Main Methods:
- Systematic review of recent publications.
- Synthesis of evidence on alcohol, blood pressure, obesity, inflammation, and nutrition.
Main Results:
- Blood pressure, hypertension, and obesity are strongly implicated in AF development.
- Preliminary evidence suggests inflammation mediates these associations.
- Alcohol and nutritional factors require further investigation.
Conclusions:
- Understanding the interplay of modifiable risk factors is crucial for developing novel AF treatments.
- Targeting risk factors like hypertension and obesity may reduce the AF burden.
Abstract:
Atrial fibrillation is the most common sustained cardiac arrhythmia in the general population. Unfortunately, current treatment strategies aiming at the elimination of atrial fibrillation have limited long term success rates and significant risks. In this context, recent publications have provided many insights on potentially treatable risk factors for the occurrence of atrial fibrillation, such as alcohol, blood pressure, obesity, inflammation and nutritional factors. In this review, we summarise the current evidence on these risk factors and indicate areas in need of further investigation. The current evidence shows that blood pressure, hypertension and obesity seem to play a key role in the pathogenesis of atrial fibrillation. Preliminary evidence also suggests that inflammation is an important mediator of these associations. Knowledge of these interrelationships may eventually help to develop new treatment strategies and decrease the burden of atrial fibrillation in the general population.
Related Concept Videos
ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias
Disturbances in Heart Rhythm
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...
Dysrhythmias III: Characteristics of Dysrhythmias
Prevalence and Incidence
Prevalence indicates the proportion of individuals in a population who have a specific disease or health condition at a...
Dysrhythmias II: Classification of Tachyarrhythmias
Dysrhythmias V: Evaluating Dysrhythmias

