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Mumps: not an innocent bystander in solid organ transplantation
M C Baas1, K A M I van Donselaar, S Florquin
1Renal Transplant Unit, Department of Nephrology, Division of Internal Medicine, Academic Medical Center, Amsterdam.
Summary
Mumps outbreaks are common, but its effects on immunocompromised individuals are not well understood. A renal transplant patient experienced irreversible transplant failure due to mumps virus-induced interstitial nephritis.
Area of Science:
- Virology
- Nephrology
- Immunology
Background:
- Recent mumps outbreaks in the UK and US highlight the virus's prevalence.
- Mumps typically presents benignly in young, healthy adults.
- Limited data exists regarding mumps infection in immunocompromised patients.
Observation:
- A 56-year-old renal transplant recipient presented with acute, irreversible transplant failure.
- The patient developed interstitial nephritis.
- Mumps virus infection was identified as the cause.
Findings:
- Mumps virus RNA was detected in the patient's urine.
- Renal biopsy confirmed the presence of mumps virus and interstitial nephritis.
- The infection led to acute irreversible transplant failure.
Implications:
- Awareness of mumps as a potential cause of severe complications in immunocompromised patients is crucial.
- Clinicians should consider mumps in the differential diagnosis of unexplained renal dysfunction in transplant recipients.
- This case underscores the importance of vaccination and monitoring in vulnerable populations.
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