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Related Experiment Video

Updated: Jun 22, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Published on: May 17, 2024

Plexiform pattern in cutaneous granular cell tumors.

Bishr Aldabagh¹, Furrukh Azmi, Manjunath Vadmal

¹Case Western Reserve School of Medicine, Cleveland, OH, USA.

Journal of Cutaneous Pathology

|July 1, 2009

Summary

Plexiform granular cell tumors, originating from peripheral nerve sheath cells, may be more common than previously thought. This study highlights nine cases with features distinct from classical cutaneous granular cell tumors.

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Area of Science:

Oncology
Dermatopathology
Surgical Pathology

Background:

Granular cell tumors (GCTs) are typically of peripheral nerve sheath origin.
Commonly affect the skin and tongue.
Classical cutaneous GCTs present as ill-defined masses with specific cellular morphology.

Purpose of the Study:

To investigate GCTs exhibiting features distinct from the classical presentation.
To evaluate the occurrence of plexiform patterns in GCTs.
To compare findings with previously described plexiform granular cell tumors.

Main Methods:

Retrospective analysis of nine GCT cases.
Histopathological examination of tumor morphology.
Comparison with classical and plexiform GCT literature.

Main Results:

Nine GCT cases showed features differing from classical cutaneous GCT.
These cases exhibited characteristics similar to plexiform granular cell tumors.
The plexiform pattern appears to be underreported in the literature.

Conclusions:

GCTs with plexiform patterns may be more prevalent than currently recognized.
Recognition of the plexiform pattern is important for accurate diagnosis and understanding of GCTs.