Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Staphylococcal Skin Infections

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...

Skin Diseases and Disorders

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

Cellular Injury IV: Necrosis

Cellular Injury IV: Necrosis

Necrosis is a form of irreversible cell death caused by severe injury such as ischemia, toxins, or trauma. Unlike programmed cell death, it is an uncontrolled, pathological process that typically provokes inflammation in surrounding tissues.Pathophysiologic ChangesNecrosis begins when cells sustain critical damage, leading to swelling of organelles, particularly mitochondria, and rapid ATP depletion. As energy levels decline, membrane ion pumps fail, leading to calcium influx and eventually,...

Necrosis

Necrosis

Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become anucleated and die, but their...

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...

Diabetic Foot Ulcer

Diabetic Foot Ulcer

Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Expanding the Histologic Spectrum of Oral Pseudoperineurioma: A Retrospective Study of 21 Cases.

Head and neck pathology·2026

Same author

Expanding the role of Mohs surgery: Management of cutaneous metastases in 3 cases.

JAAD case reports·2026

Same author

Comparative Pilot Study of Chronic Hyperplastic Candidiasis and Atypical Epithelial Proliferation With Candida Utilizing p53, p16, CD44, and OCT4 Immunohistochemistry.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·2025

Same author

Altered microRNA expression correlates with reduced TLR2/4-dependent periodontal inflammation and bone resorption induced by polymicrobial infection.

Microbiology spectrum·2025

Same author

The University of Florida Dermatopathology Experience With the Pigmented Lesion Assay.

The American Journal of dermatopathology·2025

Same author

Oral Manifestations of Pemphigus Vulgaris.

The New England journal of medicine·2025

Search research articles

Related Experiment Videos

Pyoderma gangrenosum masquerading as necrotizing fasciitis.

Keira L Barr¹, Hardeep K Chhatwal, Stanton K Wesson

¹Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, FL, USA. keirabarr@yahoo.com

American Journal of Otolaryngology

|July 1, 2009

Summary

Necrotizing fasciitis is a severe infection requiring immediate surgery and antibiotics. Pyoderma gangrenosum is an inflammatory skin condition, and distinguishing them is crucial for proper patient care.

Related Experiment Videos

Area of Science:

Dermatology
Infectious Diseases
Pathology

Background:

Necrotizing fasciitis is a rapidly progressing soft tissue infection with high morbidity and mortality.
Pyoderma gangrenosum is a non-infectious inflammatory skin condition.
Both conditions can present with extensive ulceration and necrosis, complicating diagnosis.

Observation:

A case is presented where pyoderma gangrenosum was initially misdiagnosed.
Diagnostic challenges arise from the overlapping clinical presentations of these two distinct conditions.

Findings:

Accurate diagnosis relies on meticulous clinical-pathologic correlation.
Prompt identification is essential for appropriate management and improved patient outcomes.

Implications:

Highlights the importance of considering pyoderma gangrenosum in cases of severe ulceration.
Emphasizes the need for careful differential diagnosis to avoid delayed or incorrect treatment.
Underscores the critical role of interdisciplinary collaboration in managing complex dermatologic and infectious conditions.