Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Negative Regulator Molecules

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.

Regulation of Expression at Multiple Steps

Regulation of Expression at Multiple Steps

The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the addition of a...

Master Transcription Regulators

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...

Global Regulatory Systems

Global Regulatory Systems

Global regulatory systems in bacteria enable rapid and coordinated responses to environmental changes by integrating sensory inputs with gene expression, ensuring efficient adaptation to fluctuating conditions. Key global regulatory mechanisms include regulons, two-component systems, sigma factors, and secondary messengers.Regulons and Global RegulatorsA regulon is a collection of genes and operons controlled by a common global regulator. These regulators enable bacteria to prioritize resource...

Regulation of Hematopoietic Stem Cells

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...

Positive Regulator Molecules

Positive Regulator Molecules

To consistently produce healthy cells, the cell cycle—the process that generates daughter cells—must be precisely regulated.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Perspective to precision medicine in scleroderma.

Frontiers in immunology·2024

Same author

Inhibitory role of interleukin-10 in the cutaneous reverse Arthus reaction.

The Journal of dermatology·2020

Same author

Adult-onset generalized morphea associated with osteomyelitis.

The Journal of dermatology·2020

Same author

Clinical characteristics of anti-Ro52α and anti-Ro52β antibodies in dermatomyositis/polymyositis.

Journal of dermatological science·2019

Same author

Hearing loss caused by discoid lupus erythematosus of the ear canal successfully treated with hydroxychloroquine.

The Journal of dermatology·2019

Same author

Relationship between the Degrees of Itch and Serum Lipocalin-2 Levels in Patients with Psoriasis.

Journal of immunology research·2019

Search research articles

Related Experiment Video

Updated: Jun 22, 2026

Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice

Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice

Published on: June 22, 2016

[Regulatory B cells].

Koichi Yanaba¹

¹Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, Japan.

Nihon Rinsho Men'Eki Gakkai Kaishi = Japanese Journal of Clinical Immunology

|July 1, 2009

Summary

This summary is machine-generated.

Regulatory B cells, specifically B10 cells, are crucial for immune regulation. These IL-10 producing cells, identified as CD1d(hi)CD5(+) B cells, play a key role in preventing autoimmune diseases.

More Related Videos

Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells

Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells

Published on: April 16, 2012

Related Experiment Videos

Last Updated: Jun 22, 2026

Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice

Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice

Published on: June 22, 2016

Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells

Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells

Published on: April 16, 2012

Area of Science:

Immunology
Cell Biology

Context:

B cells are known for promoting immune responses via antibody production and T cell activation.
A distinct subset of B cells, regulatory B cells, actively suppresses immune responses.
Loss of regulatory B cells exacerbates various autoimmune and inflammatory conditions in mouse models.

Purpose:

To review recent advancements in understanding IL-10-producing regulatory B cells.
To highlight the identification and characteristics of the B10 cell subset.
To explore the immunoregulatory functions of B10 cells.

Summary:

Regulatory B cells, specifically the CD1d(hi)CD5(+) B cell subset termed B10 cells, are identified as the primary producers of IL-10 within B cells.
These B10 cells share markers with B-1 and marginal zone B cells but are distinguished by their exclusive IL-10 production.
The absence or dysfunction of these regulatory B cells leads to worsened symptoms in models of experimental autoimmune encephalitis, colitis, arthritis, and diabetes.

Impact:

Advances understanding of B cell subsets and their roles in immune homeostasis.
Identifies B10 cells as a key target for therapeutic strategies in autoimmune diseases.
Provides insights into the mechanisms of immune suppression mediated by B cells.