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The effects of perindopril on aortic elasticity and inflammatory markers in hypertensive patients

Cem Koz1, Oben Baysan, Mehmet Yokusoglu

  • 1Department of Cardiology, Gulhane Military Medical School, Etlik, Ankara, Turkey.

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
|July 1, 2009
PubMed

Insights

Perindopril therapy improved aortic elasticity and reduced inflammation in hypertensive patients. This study shows perindopril

Area of Science:

  • Cardiovascular Medicine
  • Pharmacology

Background:

  • Inflammation is a key factor in hypertension and atherosclerosis.
  • Early inflammatory changes can increase arterial stiffness, even in prehypertension.
  • Perindopril's effects on inflammation and aortic elasticity were investigated.

Purpose of the Study:

  • To evaluate the impact of perindopril on aortic elastic properties.
  • To assess perindopril's effect on inflammatory markers in hypertensive patients.

Main Methods:

  • 109 hypertensive patients, treatment-naive, were enrolled.
  • Measurements included aortic strain, distensibility, stiffness index, and inflammatory markers (CRP, IL-1α, IL-1β, TNF-α).
  • Assessments were conducted before and after 20 weeks of perindopril treatment.

Main Results:

  • Perindopril significantly increased aortic strain and distensibility.
  • Aortic stiffness index and inflammatory markers showed significant decreases.
  • CRP, IL-1α, IL-1β, and TNF-α levels were reduced post-treatment.

Conclusions:

  • Perindopril therapy enhances aortic elastic properties in hypertensive individuals.
  • Perindopril treatment leads to an attenuation of the inflammatory status.
  • Reduced inflammatory marker levels indicate a beneficial effect on inflammation.
Abstract

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