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Clinical Applications of Epidermal Stem Cells

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...

Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

Cells of the Epidermis

Cells of the Epidermis

The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...

Renewal of Skin Epidermal Stem Cells

Renewal of Skin Epidermal Stem Cells

The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...

Burn Injuries

Burn Injuries

Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...

Desmosomes

Desmosomes

The term desmosome derives from the Greek words "desmo" and "soma" meaning "adhesion bodies." This structure was first observed during the late 1800s and described as small, dense nodules in the epidermis. Desmosomes are button-like structures that help form an interlinked network of intermediate filaments across the cells. These junctions are essential to hold cells together under mechanical stress and to maintain tissue integrity. Desmosomes are multi-protein complexes comprising desmosomal...

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Updated: Jun 22, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

[Epidermolysis bullosa. An update].

¹Universitäts-Hautklinik, Universitätsklinikum Freiburg, Hauptstr. 7, 79104 Freiburg. hauke.schumann@uniklinik-freiburg.de

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete

|July 1, 2009

Summary

Epidermolysis bullosa (EB) is a group of rare genetic skin disorders causing fragile skin and blisters. This review details EB subtypes, their molecular basis, and emerging treatments.

Area of Science:

Dermatology and Genetics
Rare Disease Research

Context:

Epidermolysis bullosa (EB) encompasses a spectrum of genetic disorders.
Characterized by extreme skin fragility leading to blistering upon minor trauma.
Ranges from mild forms to severe, life-threatening conditions with significant complications.

Purpose:

To present an updated classification of Epidermolysis Bullosa subtypes.
To elucidate the molecular underpinnings of different EB forms.
To review recent advancements in therapeutic strategies for EB patients.

Summary:

The review outlines the four main types of EB: EB simplex (EBS), junctional EB (JEB), dystrophic EB (DEB), and Kindler syndrome.
It incorporates the revised 2008 classification, replacing eponyms with descriptive names for 33 distinct subtypes.

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Isolation and Culture of Adult Epithelial Stem Cells from Human Skin

Isolation and Culture of Adult Epithelial Stem Cells from Human Skin

Published on: March 31, 2011

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Last Updated: Jun 22, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Isolation and Culture of Adult Epithelial Stem Cells from Human Skin

Isolation and Culture of Adult Epithelial Stem Cells from Human Skin

Published on: March 31, 2011

Discusses the genetic basis and current therapeutic options for managing EB.

Impact:

Facilitates a standardized understanding and diagnosis of diverse EB subtypes.
Provides a foundation for targeted research into the molecular mechanisms of EB.
Highlights novel therapeutic avenues for improved patient care and outcomes.