Related Experiment Video
Updated: Jun 22, 2026

Hippocampal Neuronal Cultures to Detect and Study New Pathogenic Antibodies Involved in Autoimmune Encephalitis
Published on: June 2, 2022
Autoimmune limbic encephalitis
1Department of Neurology, Haukeland University Hospital, Bergen, Norway. christian.vedeler@helse-bergen.no
Abstract:
Autoimmune limbic encephalitis (LE) can arise both by paraneoplastic and non-paraneoplastic mechanisms. Patients with LE usually have a subacute onset of memory impairment, disorientation and agitation, but can also develop seizures, hallucinations and sleep disturbance. The following investigations may aid the diagnosis: analysis of cerebrospinal fluid (CSF), electroencephalography, magnetic resonance imaging, fluorodeoxyglucose positron emission tomography and neuronal antibodies in the serum and CSF. Neuronal antibodies are sometimes, but not always, pathogenic. Autoimmune LE may respond to corticosteroids, intravenous IgG (IVIG) or plasma exchange. The cornerstone of paraneoplastic LE therapy is resection of the tumour and/or oncological treatment. Several differential diagnoses must be excluded, among them herpes simplex encephalitis.
More Related Videos
Related Concept Videos
Encephalitis l: Introduction
Encephalitis ll: Pathophysiology
Arboviral Encephalitis
Multiple Sclerosis l: Introduction
Myocarditis II: Clinical Features and Diagnostic Tests
Myasthenia Gravis ll: Pathophysiology

