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Related Experiment Video

Updated: Jun 22, 2026

Modifying Levels of Maternal Dietary Folic Acid or Choline to Study the Impact of Deficiencies on Offspring Health Outcomes

Modifying Levels of Maternal Dietary Folic Acid or Choline to Study the Impact of Deficiencies on Offspring Health Outcomes

Published on: June 28, 2024

Manganese and birth outcome.

Richard J Wood¹

¹Department of Nutrition, University of Massachusetts, Amherst, Massachusetts 01003, USA. rwood@nutrition.umass.edu

Nutrition Reviews

|July 2, 2009

Summary

Maternal manganese levels impact fetal growth. Lower manganese in pregnant individuals is linked to intrauterine growth retardation (IUGR) and lower birth weight, highlighting the need for further research.

Area of Science:

Environmental health
Human physiology
Developmental biology

Background:

Manganese is essential for fetal development and metabolism.
Manganese excess can cause neurotoxicity, particularly in infants.
The impact of manganese deficiency or excess on fetal development is not well understood.

Purpose of the Study:

To investigate the association between maternal manganese levels and fetal growth outcomes.
To understand the role of manganese in intrauterine growth retardation (IUGR) and birth weight.
To identify the need for further research on maternal-fetal manganese physiology and exposure.

Main Methods:

Review of two recent studies on maternal blood manganese and fetal development.
Epidemiological analysis of manganese exposure and birth outcomes.

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Setup of Capillary Electrophoresis-Inductively Coupled Plasma Mass Spectrometry (CE-ICP-MS) for Quantification of Iron Redox Species (Fe(II), Fe(III))

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Published on: May 4, 2020

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Last Updated: Jun 22, 2026

Modifying Levels of Maternal Dietary Folic Acid or Choline to Study the Impact of Deficiencies on Offspring Health Outcomes

Modifying Levels of Maternal Dietary Folic Acid or Choline to Study the Impact of Deficiencies on Offspring Health Outcomes

Published on: June 28, 2024

Setup of Capillary Electrophoresis-Inductively Coupled Plasma Mass Spectrometry (CE-ICP-MS) for Quantification of Iron Redox Species (Fe(II), Fe(III))

Setup of Capillary Electrophoresis-Inductively Coupled Plasma Mass Spectrometry (CE-ICP-MS) for Quantification of Iron Redox Species (Fe(II), Fe(III))

Published on: May 4, 2020

Basic research into maternal and fetal manganese physiology.

Main Results:

Lower maternal blood manganese levels are associated with fetal IUGR.
Reduced maternal manganese is linked to lower birth weight.
These findings underscore the importance of manganese for normal fetal development.

Conclusions:

Maternal manganese status is a critical factor in fetal development.
Further epidemiological and physiological studies are required to fully understand manganese's role.
Optimal manganese exposure is crucial for preventing adverse birth outcomes like IUGR.