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Analysis of baroreflex sensitivity during undulation pump ventricular assist device support.
Hongjian Liu1, Yasuyuki Shiraishi, Xiumin Zhang
1Department of Medical Engineering and Cardiology, Institute of Development, Aging and Cancer, Tohoku University, Aoba-ku, Sendai, Japan. hongjianliu63@yahoo.co.jp
Artificial Organs
|July 2, 2009
Summary
This study shows that the undulation pump ventricular assist device (UPVAD) significantly improves baroreflex sensitivity (BRS) in goats. UPVAD support enhances autonomic nervous system function, potentially benefiting microcirculation and organ function.
Area of Science:
- Cardiovascular Engineering
- Autonomic Nervous System Physiology
- Medical Device Technology
Background:
- Baroreflex sensitivity (BRS) is crucial for cardiovascular homeostasis.
- Ventricular assist devices (VADs) are vital for heart failure management.
- Assessing autonomic nervous system function during VAD support is essential.
Purpose of the Study:
- To evaluate baroreflex sensitivity (BRS) in a goat model with a chronically implanted undulation pump ventricular assist device (UPVAD).
- To investigate the impact of UPVAD support on autonomic nervous system activity.
Main Methods:
- Chronic implantation of an UPVAD in a goat model.
- Measurement of BRS using the R-R interval and mean arterial pressure relationship.
- Pharmacological induction of blood pressure changes with methoxamine hydrochloride.
- Comparison of BRS during UPVAD support versus no assistance.
Main Results:
- BRS was significantly higher during UPVAD support (1.60 ± 0.30 msec/mm Hg) compared to without assistance (0.98 ± 0.22 msec/mm Hg).
- Left ventricular assistance by the UPVAD led to a statistically significant improvement in BRS (P < 0.05).
Conclusions:
- UPVAD support significantly enhances baroreflex sensitivity in goats.
- Improved BRS suggests UPVAD may reduce sympathetic and increase parasympathetic activity.
- This modulation of autonomic function may improve microcirculation and organ perfusion.
