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Comorbidity of cardiovascular diseases with mood and anxiety disorder: a population based 4-year study
Kai-Lin Huang1, Tung-Ping Su, Tzeng-Ji Chen
1Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.
Insights
Patients with mood and anxiety disorders have a higher risk of cardiovascular diseases (CVD). Young adults under 20 experienced the highest risk, while older adults over 65 had a reduced risk. This highlights age as a key factor in mental health and heart disease links.
Area of Science:
- Cardiovascular epidemiology
- Psychiatric comorbidity
- Geriatric medicine
Background:
- Growing evidence links mood and anxiety disorders to cardiovascular diseases (CVD) in Caucasian populations.
- Limited data exists for Asian populations, and the impact of age on this association is under-researched.
Purpose of the Study:
- To investigate and compare cardiovascular comorbidities in Taiwanese patients with mood and anxiety disorders.
- To examine the influence of different age groups on the risk of CVD in these patients.
Main Methods:
- A 4-year, population-based, cross-sectional study.
- Utilized the Taiwan National Health Insurance Research Database (2000-2003).
- Included over 1 million patients with mood and anxiety disorders.
Main Results:
- Patients with mood and anxiety disorders had a significantly increased relative risk (RR) for ischemic heart disease (RR=2.0) and hypertensive disorders (RR=2.05).
- The highest RR was observed in individuals under 20 years old (RR=4.74 and 4.08, respectively).
- The lowest RR was found in individuals aged 65 and older (RR=0.47 and 0.58, respectively).
Conclusions:
- Taiwanese patients with mood and anxiety disorders exhibit substantial cardiovascular morbidity, particularly those with anxiety disorders.
- Age significantly modifies the relationship between mood, anxiety disorders, and CVD.
- Further research across diverse age groups is crucial to understand the causality and progression of CVD in individuals with mental health conditions.
Aims:
Accumulating evidence from Caucasian patients has shown that depression, bipolar and anxiety disorders are associated with an increased risk of cardiovascular diseases (CVD), but reports in the Asian population are limited, and age effect is rarely investigated. This population-based study was carried out to examine and compare the CVD comorbidities among patients with mood and anxiety disorders in different age groups.
Method:
A 4-year cross-sectional survey was carried out using the Taiwan National Health Insurance Research Database from 2000 to 2003.
Results:
An average total of 1,031,557 patients with mood and anxiety disorders were enrolled as study participants, including 76,430 cases of major depressive disorder, 41,557 cases of bipolar disorder, and 913,570 cases of anxiety disorder. When compared with the insured population without mood or anxiety disorders (average 21,356,304 people), the average relative risk (RR) of developing ischemic heart disease and hypertensive disorders in 1,031,557 study participants was 2.0 and 2.05, respectively. The highest RR was found in the age group under 20 years (RR = 4.74 and 4.08, respectively), and the lowest RR in the age group equal to or older than 65 years (RR = 0.47 and 0.58, respectively).
Conclusions:
Taiwanese patients with mood and anxiety disorders experience high cardiovascular morbidity, especially patients with anxiety disorders. Age acted as an important modifier variable that influenced the relationship between mood, anxiety disorder and CVD. This study highlights the need for future research in different age groups, in order to elucidate the causality and the trajectory of developing CVD among patients with mental disorders.
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