Related Experiment Video
Updated: Jun 22, 2026
06:46
Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
Complete pathologic response after preoperative rectal cancer chemoradiotherapy.
Anthony Ciccocioppo1, Jacqueline H Stephens, Peter J Hewett
1Colorectal Unit, Division of Surgery, The Queen Elizabeth Hospital, Woodville South, SA, Australia.
ANZ Journal of Surgery
|July 2, 2009
Summary
Patients achieving a complete pathological response (CPR) after preoperative chemoradiotherapy (CRT) for rectal cancer showed superior outcomes. None of these patients experienced recurrence or disease-related death, highlighting the significance of CPR in rectal cancer treatment.
Area of Science:
- Oncology
- Gastroenterology
- Surgical Oncology
Background:
- Preoperative chemoradiotherapy (CRT) is a standard treatment for rectal cancer.
- A complete pathological response (CPR) after CRT is an important prognostic indicator.
- Assessing outcomes based on CPR status is crucial for treatment stratification.
Purpose of the Study:
- To evaluate the long-term outcomes of rectal cancer patients who achieved a CPR after preoperative CRT.
- To compare the outcomes of patients with CPR versus those without CPR.
Main Methods:
- Retrospective analysis of rectal cancer patients treated with preoperative CRT.
- Inclusion of data from The Queen Elizabeth and Royal Adelaide hospitals (November 1998 - July 2004).
- Follow-up until January 2006 to assess disease recurrence and mortality.
Main Results:
- Out of 530 rectal cancer presentations, 40 patients received long-course preoperative CRT.
- A CPR was observed in 7 patients (17.5%) post-resection.
- Patients with CPR had no tumour recurrence or disease-related mortality after a median follow-up of 6.0 years, outperforming the non-CPR group.
Conclusions:
- Achieving a CPR following preoperative CRT in rectal cancer patients is associated with excellent long-term survival.
- No CPR patients in this cohort experienced disease recurrence or death, suggesting a potential for cure.
