[Retrospective analysis of maternal and infant birth features of hepatoblastoma patients]
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Published on: September 7, 2021
Cong-lun Pu1, Chun-bao Guo, Xian-qing Jin
1Department of Hepatobiliary Surgery, Children's Hospital, Chongqing Medical University, Chongqing, China.
Insights
Very low birth weight is a significant risk factor for hepatoblastoma. Maternal overweight and smoking also increase the risk of this childhood liver cancer.
Area of Science:
- Pediatric Oncology
- Perinatal Epidemiology
- Risk Factor Analysis
Context:
- Hepatoblastoma is a rare but serious childhood liver cancer.
- Identifying modifiable and non-modifiable risk factors is crucial for prevention and early detection strategies.
Purpose:
- To investigate infant and perinatal risk factors associated with hepatoblastoma development.
- To quantify the association between specific maternal and infant characteristics and hepatoblastoma risk.
Summary:
- A case-cohort study analyzed medical records to identify hepatoblastoma risk factors.
- Very low birth weight (<1000g) showed a strong association (OR=26.0).
- Maternal factors like older age (>35), smoking, and higher BMI were also linked to increased risk (ORs 2.6-3.2).
Impact:
- Findings highlight the importance of very low birth weight as a key risk indicator.
- Maternal health factors (overweight, smoking) are identified as significant contributors to hepatoblastoma risk.
- This research can inform public health initiatives and clinical screening protocols for high-risk infants.
Objective:
To explore the risk factors for hepatoblastoma.
Methods:
A case-cohort study using Logistic regression multiple variables analysis of medical record data sets was conducted to examine infant and perinatal risk factors for hepatoblastoma.
Results:
Birth weight less than 1,000 g was associated with a strongly increased risk of hepatoblastoma (odds risk, OR = 26.0, 95% confidence interval, CI: 14.0 to 65.7). After adjustment of birth weight, a moderately increased risk of hepatoblastoma was found for older maternal age ( > 35 years vs. 20 to 34 years: OR = 2.6, 95% CI: 0.9 to 5.9), maternal smoking (OR = 2.9, 95% CI: 1.1 to 4.2) and higher maternal pregnancy body mass index (OR = 3.2, 95% CI: 1.0 to 6.7).
Conclusion:
Very low birth weight and maternal characteristics including overweight, smoking are associated with hepatoblastoma risk.
