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Related Experiment Video

Updated: Jun 22, 2026

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods

Published on: August 4, 2022

Issues in long-term opioid therapy: unmet needs, risks, and solutions.

Steven D Passik¹

¹Department of Psychiatry and Behavioral Sciences, Memorial Sloan-Kettering Cancer Center, New York, NY 10022, USA. passiks@mskcc.org

Mayo Clinic Proceedings

|July 2, 2009

Summary

Managing chronic pain requires balancing treatment with the risks of prescription opioid abuse. Ongoing assessment and safeguards help physicians prescribe opioids safely, while abuse-deterrent formulations offer new strategies.

Related Experiment Videos

Last Updated: Jun 22, 2026

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods

Published on: August 4, 2022

Area of Science:

Pain Management
Addiction Medicine
Pharmacology

Background:

Chronic pain and prescription opioid abuse present significant public health challenges.
Healthcare professionals must balance effective pain management with mitigating opioid-related risks.

Observation:

Thorough patient assessment is crucial for developing multimodal pain treatment plans.
Identifying patients at risk for aberrant behaviors and implementing safeguards like urine drug screens is essential.

Findings:

Physicians must consider differential diagnoses for aberrant behaviors to tailor opioid therapy.
Novel abuse-deterrent opioid formulations are in development, employing strategies like combining opioids with naltrexone or niacin.

Implications:

Abuse-deterrent formulations may reduce problematic opioid use by incorporating physical and pharmacological barriers.
Non-opioid medications and non-pharmacological interventions are vital for patients unable to manage opioid therapy safely.