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Related Concept Videos

Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not necessarily...
Drug Dependence01:17

Drug Dependence

Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
Pharmacodynamics: Overview and Principles01:21

Pharmacodynamics: Overview and Principles

Pharmacodynamics is a scientific field that delves into drugs' intricate biochemical, cellular, and physiological effects on the human body. The study of pharmacodynamics helps us understand how drugs interact with the body and elicit various responses.
Most drugs' effects result from their interactions with drug receptors or targets within the body. These interactions trigger specific responses at the cellular or systemic level. Drug receptors can be found on the surfaces of cells or within...
Drug Toxicity: Dose-Dependent Reactions01:24

Drug Toxicity: Dose-Dependent Reactions

Drug toxicities can be stratified into pharmacological, pathological, or genotoxic based on their mechanisms. The incidence and severity of these toxicities generally increase with the drug's concentration in the body and exposure time.Pharmacological toxicity is evident when the therapeutic effects of drugs overshoot into adverse reactions in a predictable, dose-dependent manner. Central nervous system (CNS) depression from barbiturates is a classic example, with effects escalating from...
Pharmaceutical Poisoning: Potential Scenarios01:26

Pharmaceutical Poisoning: Potential Scenarios

Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...

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Related Experiment Video

Updated: Jun 22, 2026

Formation of Covalent DNA Adducts by Enzymatically Activated Carcinogens and Drugs In Vitro and Their Determination by 32P-postlabeling
09:33

Formation of Covalent DNA Adducts by Enzymatically Activated Carcinogens and Drugs In Vitro and Their Determination by 32P-postlabeling

Published on: March 20, 2018

Chemical dependency and the physician.

Keith H Berge1, Marvin D Seppala, Agnes M Schipper

  • 1Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA. berge.keith@mayo.edu

Mayo Clinic Proceedings
|July 2, 2009
PubMed
Summary

Physician addiction is as prevalent as in the general population but often diagnosed late. Early intervention and workplace policies are crucial for treating addicted physicians and ensuring patient safety.

Area of Science:

  • Medical Ethics
  • Addiction Medicine
  • Public Health

Background:

  • Physician addiction is a significant issue, often overlooked by the public.
  • Physicians exhibit addiction rates similar to or exceeding the general population.
  • Addiction in physicians is frequently diagnosed at advanced stages, delaying intervention.

Purpose of the Study:

  • To provide an overview of physician addiction, including its scope and risks.
  • To discuss challenges in recognizing and intervening in physician addiction.
  • To explore treatment, aftercare, and ethical/legal considerations for addicted physicians.

Main Methods:

  • Literature review and synthesis of existing research on physician addiction.
  • Analysis of diagnostic delays and contributing factors.

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Last Updated: Jun 22, 2026

Formation of Covalent DNA Adducts by Enzymatically Activated Carcinogens and Drugs In Vitro and Their Determination by 32P-postlabeling
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A Bilingual Computational Workflow for Identifying Potential PLK1 Inhibitors in American Sign Language and English
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  • Examination of treatment modalities and aftercare protocols.
  • Main Results:

    • Physicians' tendency to protect professional image delays diagnosis and intervention.
    • Advanced-stage addiction presents unique challenges for treatment and recovery.
    • Ethical and legal implications arise concerning impaired physicians returning to practice.

    Conclusions:

    • Implementing clear workplace policies for addiction is critical.
    • Policies should aim to minimize adverse medical/legal outcomes.
    • Appropriate care and monitored aftercare are essential for addicted physicians' recovery and public safety.